RecA-mediated sequence homology recognition as an example of how searching speed in self-assembly systems can be optimized by balancing entropic and enthalpic barriers
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CitationJiang, Lili, and Mara Prentiss. 2014. “RecA-Mediated Sequence Homology Recognition as an Example of How Searching Speed in Self-Assembly Systems Can Be Optimized by Balancing Entropic and Enthalpic Barriers.” Physical Review E 90 (2). https://doi.org/10.1103/physreve.90.022704.
AbstractIdeally, self-assembly should rapidly and efficiently produce stable correctly assembled structures. We study the tradeoff between enthalpic and entropic cost in self-assembling systems using RecA-mediated homology search as an example. Earlier work suggested that RecA searches could produce stable final structures with high stringency using a slow testing process that follows an initial rapid search of similar to 9-15 bases. In this work, we will show that as a result of entropic and enthalpic barriers, simultaneously testing all similar to 9-15 bases as separate individual units results in a longer overall searching time than testing them in groups and stages.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41461288
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