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dc.contributor.authorJiang, Lili
dc.contributor.authorPrentiss, Mara
dc.date.accessioned2019-10-03T14:39:44Z
dc.date.issued2014
dc.identifier.citationJiang, Lili, and Mara Prentiss. 2014. “RecA-Mediated Sequence Homology Recognition as an Example of How Searching Speed in Self-Assembly Systems Can Be Optimized by Balancing Entropic and Enthalpic Barriers.” Physical Review E 90 (2). https://doi.org/10.1103/physreve.90.022704.
dc.identifier.issn1539-3755
dc.identifier.issn1550-2376
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41461288*
dc.description.abstractIdeally, self-assembly should rapidly and efficiently produce stable correctly assembled structures. We study the tradeoff between enthalpic and entropic cost in self-assembling systems using RecA-mediated homology search as an example. Earlier work suggested that RecA searches could produce stable final structures with high stringency using a slow testing process that follows an initial rapid search of similar to 9-15 bases. In this work, we will show that as a result of entropic and enthalpic barriers, simultaneously testing all similar to 9-15 bases as separate individual units results in a longer overall searching time than testing them in groups and stages.
dc.language.isoen_US
dc.publisherAmerican Physical Society
dash.licenseOAP
dc.titleRecA-mediated sequence homology recognition as an example of how searching speed in self-assembly systems can be optimized by balancing entropic and enthalpic barriers
dc.typeJournal Article
dc.description.versionAccepted Manuscript
dc.relation.journalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
dash.depositing.authorPrentiss, Mara::6d301a8de03860625d7558e450f9a0ca::600
dc.date.available2019-10-03T14:39:44Z
dash.workflow.comments1Science Serial ID 80538
dc.identifier.doi10.1103/PhysRevE.90.022704
dash.source.volume90;2
dash.source.page22704


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