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dc.contributor.authorTerasawa, Masahiro
dc.contributor.authorOgawa, Hideyuki
dc.contributor.authorTsukamoto, Yasumasa
dc.contributor.authorShinohara, Miki
dc.contributor.authorShirahige, Katsuhiko
dc.contributor.authorKleckner, Nancy
dc.contributor.authorOgawa, Tomoko
dc.date.accessioned2019-10-03T17:41:02Z
dc.date.issued2007
dc.identifier.citationTerasawa, M., H. Ogawa, Y. Tsukamoto, M. Shinohara, K. Shirahige, N. Kleckner, and T. Ogawa. 2007. “Meiotic Recombination-Related DNA Synthesis and Its Implications for Cross-over and Non-Cross-over Recombinant Formation.” Proceedings of the National Academy of Sciences 104 (14): 5965–70. https://doi.org/10.1073/pnas.0611490104.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41467399*
dc.description.abstractMeiotic recombination-related DNA synthesis (MRDS) was analyzed in Saccharomyces cerevisiae by specifically timed incorporation of thymidine analogs into chromosomes. Lengths and positions of incorporation tracts were determined relative to a known recombination hot spot along DNA, as was the timing and localization of incorporation relative to forming and formed synaptonemal complex in spread chromosomes. Distinct patterns could be specifically associated with the majority cross-over and non-cross-over recombination processes. The results obtained provide direct evidence for key aspects of current consensus recombination models, provide information regarding temporal and spatial relationships between non-cross-over formation and the synaptonemal complex, and raise the possibility that removal of RecA homolog Rad51 plays a key role in regulating onset of MRDS. Finally, classical observations on MRDS in Drosophila, mouse, and lily are readily mapped onto the findings presented here, providing further evidence for a broadly conserved meiotic recombination process.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleMeiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorKleckner, Nancy Elizabeth::f5e44fcf9b08dbb871ef3e73ac14b7e5::600
dc.date.available2019-10-03T17:41:02Z
dash.workflow.comments1Science Serial ID 90088
dc.identifier.doi10.1073/pnas.0611490104
dash.source.volume104;14
dash.source.page5965


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