Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen
Peng, Lee F.
Kim, Sun Suk
Beeler, Aaron B.
Porco, John A. Jr.
Schreiber, Stuart L.
Chung, Raymond T.
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CitationPeng, L. F., S. S. Kim, S. Matchacheep, X. Lei, S. Su, W. Lin, W. Runguphan, et al. 2007. “Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen.” Antimicrobial Agents and Chemotherapy 51 (10): 3756–59. https://doi.org/10.1128/aac.00233-07.
AbstractUsing our high-throughput hepatitis C replicon assay to screen a library of over 8,000 novel diversity-oriented synthesis (DOS) compounds, we identified several novel compounds that regulate hepatitis C virus (HCV) replication, including two libraries of epoxides that inhibit HCV replication (best 50% effective concentration, < 0.5 mu M). We then synthesized an analog of these compounds with optimized activity.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41467430
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