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dc.contributor.authorYou, Angie
dc.contributor.authorTong, Jeffrey K.
dc.contributor.authorGrozinger, Christina M.
dc.contributor.authorSchreiber, Stuart L.
dc.date.accessioned2019-10-03T17:42:23Z
dc.date.issued2001
dc.identifier.citationYou, A., J. K. Tong, C. M. Grozinger, and S. L. Schreiber. 2001. “CoREST Is an Integral Component of the CoREST- Human Histone Deacetylase Complex.” Proceedings of the National Academy of Sciences 98 (4): 1454–58. https://doi.org/10.1073/pnas.98.4.1454.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41467498*
dc.description.abstractHere we describe the components of a histone deacetylase (HDAC) complex that we term the CoREST-HDAC complex. CoREST-HDAC is composed of polypeptides distinct from previously characterized HDAC1/2-containing complexes such as the mSin3 and nucleosome remodeling and deacetylating (NRD, also named NURD, NuRD) complex. Interestingly, we do not observe RbAp46 and RbAp48 in this complex, although these proteins have been observed in all previously identified complexes and are thought to be part of an HDAC1/2 core. We identify the transcriptional corepressor CoREST and a protein with homology to polyamine oxidases as components of CoREST-HDAC. The HDAC1/2-interacting region of CoREST is mapped to a 179-aa region containing a SANT domain, a domain found in other HDAC1/2-interacting proteins such as NCoR, MTA1, and MTA2. Furthermore, we demonstrate that the corepressor function of CoREST depends on this region. Although CoREST initially was cloned as a corepressor to REST (RE1 silencing transcription factor/neural restrictive silencing factor), we find no evidence for the existence of the eight-zinc finger REST transcription factor as an interacting partner in this complex; however, we do find evidence for association of the putative oncogene ZNF 217 that contains eight zinc fingers.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleCoREST is an integral component of the CoREST- human histone deacetylase complex
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorSchreiber, Stuart L.::80f648d0514e642a8f97bb9b12b10db7::600
dc.date.available2019-10-03T17:42:23Z
dash.workflow.comments1Science Serial ID 89253
dc.identifier.doi10.1073/pnas.98.4.1454
dash.source.volume98;4
dash.source.page1454


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