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dc.contributor.authorAvruch, Joseph
dc.contributor.authorXavier, Ramnik
dc.contributor.authorBardeesy, Nabeel
dc.contributor.authorZhang, Xian-feng
dc.contributor.authorPraskova, Maria
dc.contributor.authorZhou, Dawang
dc.contributor.authorXia, Fan
dc.date.accessioned2019-10-05T03:28:29Z
dc.date.issued2009
dc.identifier.citationAvruch, Joseph, Ramnik Xavier, Nabeel Bardeesy, Xian-feng Zhang, Maria Praskova, Dawang Zhou, and Fan Xia. 2008. “Rassf Family of Tumor Suppressor Polypeptides.” Journal of Biological Chemistry 284 (17): 11001–5. https://doi.org/10.1074/jbc.r800073200.
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483004*
dc.description.abstractThe Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and proapoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleRassf Family of Tumor Suppressor Polypeptides
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Biological Chemistry
dash.depositing.authorAvruch, Joseph::9aac9685759478ee19677d9b77258031::600
dc.date.available2019-10-05T03:28:29Z
dash.workflow.comments1Science Serial ID 109641
dc.identifier.doi10.1074/jbc.R800073200
dash.source.volume284;17
dash.source.page11001


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