Show simple item record

dc.contributor.authorKyriakis, John M.
dc.contributor.authorAvruch, Joseph
dc.date.accessioned2019-10-05T03:29:18Z
dc.date.issued1996
dc.identifier.citationKyriakis, John M., and Joseph Avruch. 1996. “Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation.” Journal of Biological Chemistry 271 (40): 24313–16. https://doi.org/10.1074/jbc.271.40.24313.
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483055*
dc.description.abstractEukaryotic cells respond to extracellular stimuli by recruiting signal transduction pathways, many of which employ protein Ser/Thr kinases of the ERK(1) family. The ubiquity of ERKs and their upstream activators, the MEKs, in signal transduction was first appreciated from studies of yeast (1, 2). Although a 54-kDa rat liver c-Jun kinase (SAPK-p54 alpha 1) with properties similar to the Ras-regulated MAPKs had been characterized (3-5), the physiologic roles and regulation of this and related mammalian enzymes have emerged only recently. Molecular cloning of the SAPKs and p38s, together with the paradigms derived from the ''classical'' MAPKs and work in lower eukaryotes has enabled rapid elucidation of the regulation and cellular functions of these newer mammalian ERK pathways. Although architecturally homologous to the Ras/MAPK pathway, the SAPK and p38 pathways are not activated primarily by mitogens but by cellular stresses and inflammatory cytokines, which stimuli result in growth arrest, apoptosis, or activation of immune and reticuloendothelial cells.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleSounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Biological Chemistry
dash.depositing.authorAvruch, Joseph::9aac9685759478ee19677d9b77258031::600
dc.date.available2019-10-05T03:29:18Z
dash.workflow.comments1Science Serial ID 105319
dc.identifier.doi10.1074/jbc.271.40.24313
dash.source.volume271;40
dash.source.page24313-24316


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record