Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: the Receptor as a Catalyst
Tsang, Simon K.
McDermott, Brian M.
Racaniello, Vincent R.
Hogle, James M.
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CitationTsang, S. K., B. M. McDermott, V. R. Racaniello, and J. M. Hogle. 2001. “Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: The Receptor as a Catalyst.” Journal of Virology 75 (11): 4984–89. https://doi.org/10.1128/jvi.75.11.4984-4989.2001.
AbstractWe examined the role of soluble poliovirus receptor on the transition of native poliovirus (160S or N particle) to an infectious intermediate (135S or A particle). The viral receptor behaves as a classic transition state theory catalyst, facilitating the N-to-A conversion by lowering the activation energy for the process by 50 kcal/mol, in contrast to earlier studies which demonstrated that capsid-binding drugs inhibit thermally mediated N-to-A conversion through entropic stabilization alone, capsid-binding drugs are shown to inhibit receptor-mediated N-to-A conversion through a combination of enthalpic and entropic effects.
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