Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism

Abstract

Background: Association of the proteasome core with activators regulates proteasome activity. Results: Blm10 association increases proteasome activity toward peptides and the unstructured proteasome substrate tau-441. This process is mediated by the C terminus of Blm10. Conclusion: C-terminal docking-mediated proteasome activation by Blm10 facilitates the turnover of peptide and protein substrates.Significance: Blm10 contributes to the regulation of proteasome activity.