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dc.contributor.authorJogler, Christian
dc.contributor.authorWaldmann, Jost
dc.contributor.authorHuang, Xiaoluo
dc.contributor.authorJogler, Mareike
dc.contributor.authorGlöckner, Frank Oliver
dc.contributor.authorMascher, Thorsten
dc.contributor.authorKolter, Roberto
dc.date.accessioned2019-10-05T09:47:29Z
dc.date.issued2012
dc.identifier.citationJogler, Christian, Jost Waldmann, Xiaoluo Huang, Mareike Jogler, Frank Oliver Glöckner, Thorsten Mascher, and Roberto Kolter. 2012. “Identification of Proteins Likely To Be Involved in Morphogenesis, Cell Division, and Signal Transduction in Planctomycetes by Comparative Genomics.” Journal of Bacteriology 194 (23): 6419–30. https://doi.org/10.1128/jb.01325-12.
dc.identifier.issn0021-9193
dc.identifier.issn1067-8832
dc.identifier.issn1098-5530
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483200*
dc.description.abstractMembers of the Planctomycetes clade share many unusual features for bacteria. Their cytoplasm contains membrane-bound compartments, they lack peptidoglycan and FtsZ, they divide by polar budding, and they are capable of endocytosis. Planctomycete genomes have remained enigmatic, generally being quite large (up to 9 Mb), and on average, 55% of their predicted proteins are of unknown function. Importantly, proteins related to the unusual traits of Planctomycetes remain largely unknown. Thus, we embarked on bioinformatic analyses of these genomes in an effort to predict proteins that are likely to be involved in compartmentalization, cell division, and signal transduction. We used three complementary strategies. First, we defined the Planctomycetes core genome and subtracted genes of well-studied model organisms. Second, we analyzed the gene content and synteny of morphogenesis and cell division genes and combined both methods using a "guilt-by-association" approach. Third, we identified signal transduction systems as well as sigma factors. These analyses provide a manageable list of candidate genes for future genetic studies and provide evidence for complex signaling in the Planctomycetes akin to that observed for bacteria with complex life-styles, such as Myxococcus xanthus.
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dash.licenseLAA
dc.titleIdentification of Proteins Likely to Be Involved in Morphogenesis, Cell Division, and Signal Transduction in Planctomycetes by Comparative Genomics
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of Bacteriology
dash.depositing.authorKolter, Roberto::f54296e17449791d262d990800c17d94::600
dc.date.available2019-10-05T09:47:29Z
dash.workflow.comments1Science Serial ID 50409
dc.identifier.doi10.1128/JB.01325-12
dash.source.volume194;23
dash.source.page6419


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