Show simple item record

dc.contributor.authorYamaichi, Yoshiharu
dc.contributor.authorBruckner, Raphael
dc.contributor.authorRinggaard, Simon
dc.contributor.authorMöll, Andrea
dc.contributor.authorCameron, D. Ewen
dc.contributor.authorBriegel, Ariane
dc.contributor.authorJensen, Grant
dc.contributor.authorDavis, Brigid
dc.contributor.authorWaldor, Matthew
dc.date.accessioned2019-10-05T16:04:45Z
dc.date.issued2012
dc.identifier.citationYamaichi, Y., R. Bruckner, S. Ringgaard, A. Moll, D. E. Cameron, A. Briegel, G. J. Jensen, B. M. Davis, and M. K. Waldor. 2012. “A Multidomain Hub Anchors the Chromosome Segregation and Chemotactic Machinery to the Bacterial Pole.” Genes & Development 26 (20): 2348–60. https://doi.org/10.1101/gad.199869.112.
dc.identifier.issn0890-9369
dc.identifier.issn1549-5477
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483468*
dc.description.abstractThe cell poles constitute key subcellular domains that are often critical for motility, chemotaxis, and chromosome segregation in rod-shaped bacteria. However, in nearly all rods, the processes that underlie the formation, recognition, and perpetuation of the polar domains are largely unknown. Here, in Vibrio cholerae, we identified HubP (hub of the pole), a polar transmembrane protein conserved in all vibrios, that anchors three ParA-like ATPases to the cell poles and, through them, controls polar localization of the chromosome origin, the chemotactic machinery, and the flagellum. In the absence of HubP, oriCI is not targeted to the cell poles, chemotaxis is impaired, and a small but increased fraction of cells produces multiple, rather than single, flagella. Distinct cytoplasmic domains within HubP are required for polar targeting of the three ATPases, while a periplasmic portion of HubP is required for its localization. HubP partially relocalizes from the poles to the mid-cell prior to cell division, thereby enabling perpetuation of the polar domain
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Press
dash.licenseLAA
dc.titleA multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalGenes & Development
dash.depositing.authorWaldor, Matthew K::d323ffce6ff0937ea2fb987a38019253::600
dc.date.available2019-10-05T16:04:45Z
dash.workflow.comments1Science Serial ID 43633
dc.identifier.doi10.1101/gad.199869.112
dash.source.volume26;20
dash.source.page2348


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record