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dc.contributor.authorYuan, Junying
dc.contributor.authorKroemer, Guido
dc.date.accessioned2019-10-05T16:04:53Z
dc.date.issued2010
dc.identifier.citationYuan, J., and G. Kroemer. 2010. “Alternative Cell Death Mechanisms in Development and beyond.” Genes & Development 24 (23): 2592–2602. https://doi.org/10.1101/gad.1984410.
dc.identifier.issn0890-9369
dc.identifier.issn1549-5477
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483474*
dc.description.abstractA canonical regulatory pathway involving the members of the Bcl-2 and caspase families has been established to regulate developmental apoptosis in nematodes and flies. However, mutant mice that have major deficiencies in this apoptosis pathway show only relatively minor developmental defects. Recent revelations indicate that multiple mechanisms are involved in regulating cell death during mammalian development, tissue homeostasis, and pathological cell loss. Here, we critically evaluate the evidence demonstrating the existence of alternative cell death mechanisms, including apoptosis of lower organisms in the absence of canonical apoptosis mediators, autophagic cell death, necroptosis, elimination by shedding, keratinocyte death by cornification, and cell-cell cannibalism by entosis. The physiological relevance of alternative cell death mechanisms as primary and backup mechanisms is discussed.
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Press
dash.licenseLAA
dc.titleAlternative cell death mechanisms in development and beyond
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalGenes & Development
dash.depositing.authorYuan, Junying::c7e832b918fc7c2356d6c49fe1a0b135::600
dc.date.available2019-10-05T16:04:53Z
dash.workflow.comments1Science Serial ID 41787
dc.identifier.doi10.1101/gad.1984410
dash.source.volume24;23
dash.source.page2592


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