The Docosatriene Protectin D1 Is Produced by T H 2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering
Author
Ariel, Amiram
Li, Pin-Lan
Wang, Wei
Tang, Wang-Xian
Fredman, Gabrielle
Hong, Song
Gotlinger, Katherine H.
Serhan, Charles N.
Published Version
https://doi.org/10.1074/jbc.M509796200Metadata
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Ariel, Amiram, Pin-Lan Li, Wei Wang, Wang-Xian Tang, Gabrielle Fredman, Song Hong, Katherine H. Gotlinger, and Charles N. Serhan. 2005. “The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering.” Journal of Biological Chemistry 280 (52): 43079–86. https://doi.org/10.1074/jbc.m509796200.Abstract
Docosahexaenoic acid, a major omega-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated. In this study we found, using lipid mediator informatics employing liquid chromatography-tandem mass spectrometry, that (10, 17S)-docosatriene/neuroprotectin D1, now termed protectin D1 (PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood mononuclear cells in a lipoxygenase-dependent manner. PD1 blocked T cell migration in vivo, inhibited tumor necrosis factor alpha and interferon-gamma secretion, and promoted apoptosis mediated by raft clustering. These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution.Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483487
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