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dc.contributor.authorAriel, Amiram
dc.contributor.authorLi, Pin-Lan
dc.contributor.authorWang, Wei
dc.contributor.authorTang, Wang-Xian
dc.contributor.authorFredman, Gabrielle
dc.contributor.authorHong, Song
dc.contributor.authorGotlinger, Katherine H.
dc.contributor.authorSerhan, Charles N.
dc.date.accessioned2019-10-05T16:05:02Z
dc.date.issued2005
dc.identifier.citationAriel, Amiram, Pin-Lan Li, Wei Wang, Wang-Xian Tang, Gabrielle Fredman, Song Hong, Katherine H. Gotlinger, and Charles N. Serhan. 2005. “The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering.” Journal of Biological Chemistry 280 (52): 43079–86. https://doi.org/10.1074/jbc.m509796200.
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483487*
dc.description.abstractDocosahexaenoic acid, a major omega-3 fatty acid in human brain, synapses, retina, and other neural tissues, displays beneficial actions in neuronal development, cancer, and inflammatory diseases by mechanisms that remain to be elucidated. In this study we found, using lipid mediator informatics employing liquid chromatography-tandem mass spectrometry, that (10, 17S)-docosatriene/neuroprotectin D1, now termed protectin D1 (PD1), is generated from docosahexaenoic acid by T helper type 2-skewed peripheral blood mononuclear cells in a lipoxygenase-dependent manner. PD1 blocked T cell migration in vivo, inhibited tumor necrosis factor alpha and interferon-gamma secretion, and promoted apoptosis mediated by raft clustering. These results demonstrated novel anti-inflammatory roles for PD1 in regulating events associated with inflammation and resolution.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleThe Docosatriene Protectin D1 Is Produced by T H 2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Biological Chemistry
dash.depositing.authorSerhan, Charles Nicholas::40628494470cc50c44bd3fc1053e7d94::600
dc.date.available2019-10-05T16:05:02Z
dash.workflow.comments1Science Serial ID 106346
dc.identifier.doi10.1074/jbc.M509796200
dash.source.volume280;52
dash.source.page43079-43086


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