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dc.contributor.authorDing, Han-Fei
dc.contributor.authorLin, Yi-Ling
dc.contributor.authorMcGill, Gaël
dc.contributor.authorJuo, Peter
dc.contributor.authorZhu, Hong
dc.contributor.authorBlenis, John
dc.contributor.authorYuan, Junying
dc.contributor.authorFisher, David E.
dc.date.accessioned2019-10-05T16:05:04Z
dc.date.issued2000
dc.identifier.citationDing, Han-Fei, Yi-Ling Lin, Gaël McGill, Peter Juo, Hong Zhu, John Blenis, Junying Yuan, and David E. Fisher. 2000. “Essential Role for Caspase-8 in Transcription-Independent Apoptosis Triggered by p53.” Journal of Biological Chemistry 275 (49): 38905–11. https://doi.org/10.1074/jbc.m004714200.
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483491*
dc.description.abstractp53's dual regulation of arrest versus apoptosis may underlie tumor-selective effects of anti-cancer therapy. p53's apoptotic effect has been suggested to involve both transcription-dependent and -independent mechanisms. It is shown here that caspase-8 is activated early in cells undergoing p53-mediated apoptosis and in S100 cell-free extracts that recapitulate transcription-independent apoptosis, Depletion or inactivation of caspase-8 either in cells or cell-free extracts completely prevents this transcription-independent apoptosis and significantly attenuates overall death induced by wildtype p53. Importantly, caspase-8 activation appears to be independent of FADD, and caspase-8 is found in a novel 600-kDa complex following p53 activation. These findings highlight the roles of both transcription-dependent and -independent apoptosis by p53 and identify an essential role for caspase-8 in the transcription-independent pathway.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleEssential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Biological Chemistry
dash.depositing.authorYuan, Junying::c7e832b918fc7c2356d6c49fe1a0b135::600
dc.date.available2019-10-05T16:05:04Z
dash.workflow.comments1Science Serial ID 105772
dc.identifier.doi10.1074/jbc.M004714200
dash.source.volume275;49
dash.source.page38905-38911


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