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dc.contributor.authorArita, Makoto
dc.contributor.authorBianchini, Francesca
dc.contributor.authorAliberti, Julio
dc.contributor.authorSher, Alan
dc.contributor.authorChiang, Nan
dc.contributor.authorHong, Song
dc.contributor.authorYang, Rong
dc.contributor.authorPetasis, Nicos A.
dc.contributor.authorSerhan, Charles N.
dc.date.accessioned2019-10-05T16:05:21Z
dc.date.issued2005
dc.identifier.citationArita, Makoto, Francesca Bianchini, Julio Aliberti, Alan Sher, Nan Chiang, Song Hong, Rong Yang, Nicos A. Petasis, and Charles N. Serhan. 2005. “Stereochemical Assignment, Antiinflammatory Properties, and Receptor for the Omega-3 Lipid Mediator Resolvin E1.” The Journal of Experimental Medicine 201 (5): 713–22. https://doi.org/10.1084/jem.20042031.
dc.identifier.issn0021-9525
dc.identifier.issn1540-8140
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483509*
dc.description.abstractThe essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease. Resolvin E1 (RvE1), a new bioactive oxygenated product of EPA, was identified in human plasma and prepared by total organic synthesis. Results of bioaction and physical matching studies indicate that the complete structure of RvE1 is 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA. At nanomolar levels, RvE1 dramatically reduced dermal inflammation, peritonitis, dendritic cell (DC) migration, and interleukin (IL) 12 production. We screened receptors and identified one, denoted earlier as ChemR23, that mediates RvE1 signal to attenuate nuclear factor-kappa B. Specific binding of RvE1 to this receptor was confirmed using synthetic [H-3]-labeled RvE1. Treatment of DCs with small interference RNA specific for ChemR23 sharply reduced RvE1 regulation of IL-12. These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation.
dc.language.isoen_US
dc.publisherRockefeller University Press
dash.licenseLAA
dc.titleStereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Cell Biology
dash.depositing.authorSerhan, Charles Nicholas::40628494470cc50c44bd3fc1053e7d94::600
dc.date.available2019-10-05T16:05:21Z
dash.workflow.comments1Science Serial ID 110665
dc.identifier.doi10.1084/jem.20042031
dash.source.volume201;5


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