dc.contributor.author | Li, Juying | |
dc.contributor.author | Yin, Helen L. | |
dc.contributor.author | Yuan, Junying | |
dc.date.accessioned | 2019-10-05T16:05:31Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Li, Juying, Helen L. Yin, and Junying Yuan. 2008. “Flightless-I Regulates Proinflammatory Caspases by Selectively Modulating Intracellular Localization and Caspase Activity.” The Journal of Cell Biology 181 (2): 321–33. https://doi.org/10.1083/jcb.200711082. | |
dc.identifier.issn | 0021-9525 | |
dc.identifier.issn | 1540-8140 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483524 | * |
dc.description.abstract | Caspase-1 and caspase-11 are proinflammatory caspases that regulate cytokine production and leukocyte migration during pathogen infection. In an attempt to identify new intracellular regulators of caspase-11, we found that Flightless-I, a member of the gelsolin superfamily of actin-remodeling proteins, interacts and regulates both caspase-11 and caspase-1. Flightless-I targets caspase-11 to the Triton X-100- insoluble cytoskeleton fraction and the cell leading edge. In addition, Flightless-I inhibits caspase-1 activation and caspase-1-mediated interleukine-1 beta (IL-1 beta) maturation. The physiological relevance of these findings is supported by the opposing effects of Flightless-I overexpression and knockdown on caspase-1 activity and IL-1 beta maturation. Our results suggest that Flightless-I may be a bona. de caspase-1 inhibitor that acts through a mechanism similar to that of cytokine response modi. er A, a potent caspase-1 inhibitor from the cowpox virus. Our study provides a new mechanism controlling the localization and activation of proinflammatory caspases. | |
dc.language.iso | en_US | |
dc.publisher | Rockefeller University Press | |
dash.license | LAA | |
dc.title | Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | The Journal of Cell Biology | |
dash.depositing.author | Yuan, Junying::c7e832b918fc7c2356d6c49fe1a0b135::600 | |
dc.date.available | 2019-10-05T16:05:31Z | |
dash.workflow.comments | 1Science Serial ID 108910 | |
dc.identifier.doi | 10.1083/jcb.200711082 | |
dash.source.volume | 181;2 | |