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dc.contributor.authorBazan, Nicolas G.
dc.contributor.authorCalandria, Jorgelina M.
dc.contributor.authorSerhan, Charles N.
dc.date.accessioned2019-10-05T16:05:36Z
dc.date.issued2010
dc.identifier.citationBazan, Nicolas G., Jorgelina M. Calandria, and Charles N. Serhan. 2010. “Rescue and Repair during Photoreceptor Cell Renewal Mediated by Docosahexaenoic Acid-Derived Neuroprotectin D1.” Journal of Lipid Research 51 (8): 2018–31. https://doi.org/10.1194/jlr.r001131.
dc.identifier.issn0022-2275
dc.identifier.issn1539-7262
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41483531*
dc.description.abstractRetinal degenerative diseases result in retinal pigment epithelial (RPE) and photoreceptor cell loss. These cells are continuously exposed to the environment (light) and to potentially pro-oxidative conditions, as the retina's oxygen consumption is very high. There is also a high flux of docosahexaenoic acid (DHA), a PUFA that moves through the blood stream toward photoreceptors and between them and RPE cells. Photoreceptor outer segment shedding and phagocytosis intermittently renews photoreceptor membranes. DHA is converted through 15-lipoxygenase-1 into neuroprotectin D1 (NPD1), a potent mediator that evokes counteracting cell-protective, anti-inflammatory, pro-survival repair signaling, including the induction of anti-apoptotic proteins and inhibition of pro-apoptotic proteins. Thus, NPD1 triggers activation of signaling pathway/s that modulate/s pro-apoptotic signals, promoting cell survival. This review provides an overview of DHA in photoreceptors and describes the ability of RPE cells to synthesize NPD1 from DHA. It also describes the role of neurotrophins as agonists of NPD1 synthesis and how photoreceptor phagocytosis induces refractoriness to oxidative stress in RPE cells, with concomitant NPD1 synthesis.-Bazan, N. G., J. M. Calandria, and C. N. Serhan. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J. Lipid Res. 2010. 51: 2018-2031.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleRescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Lipid Research
dash.depositing.authorSerhan, Charles Nicholas::40628494470cc50c44bd3fc1053e7d94::600
dc.date.available2019-10-05T16:05:36Z
dash.workflow.comments1Science Serial ID 110331
dc.identifier.doi10.1194/jlr.R001131
dash.source.volume51;8
dash.source.page2018


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