Origins of Elasticity in Intermediate Filament Networks
View/ Open
Author
Lin, Yi-Chia
Yao, Norman Y.
Broedersz, Chase P.
Herrmann, Harald
MacKintosh, Fred C.
Weitz, David A.
Published Version
https://doi.org/10.1103/PhysRevLett.104.058101Metadata
Show full item recordCitation
Lin, Yi-Chia, Norman Y. Yao, Chase P. Broedersz, Harald Herrmann, Fred C. MacKintosh, and David A. Weitz. 2010. “Origins of Elasticity in Intermediate Filament Networks.” Physical Review Letters104 (5): 058101. https://doi.org/10.1103/PhysRevLett.104.058101.Abstract
Intermediate filaments are common structural elements found in abundance in all metazoan cells, where they form networks that contribute to the elasticity. Here, we report measurements of the linear and nonlinear viscoelasticity of networks of two distinct intermediate filaments, vimentin and neurofilaments. Both exhibit predominantly elastic behavior with strong nonlinear strain stiffening. We demonstrate that divalent ions behave as effective cross-linkers for both networks, and that the elasticity of these networks is consistent with the theory for that of semiflexible polymers.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41511267
Collections
- FAS Scholarly Articles [17845]
Contact administrator regarding this item (to report mistakes or request changes)