Sequence correlations shape protein promiscuity
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Author
Lukatsky, David B.
Afek, Ariel
Shakhnovich, Eugene I.
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https://doi.org/10.1063/1.3624332Metadata
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Lukatsky, David B., Ariel Afek, and Eugene I. Shakhnovich. 2011. “Sequence Correlations Shape Protein Promiscuity.” The Journal of Chemical Physics135 (6): 065104. https://doi.org/10.1063/1.3624332.Abstract
We predict analytically that diagonal correlations of amino acid positions within protein sequences statistically enhance protein propensity for nonspecific binding. We use the term "promiscuity" to describe such nonspecific binding. Diagonal correlations represent statistically significant repeats of sequence patterns where amino acids of the same type are clustered together. The predicted effect is qualitatively robust with respect to the form of the microscopic interaction potentials and the average amino acid composition. Our analytical results provide an explanation for the enhanced diagonal correlations observed in hubs of eukaryotic organismal proteomes [J. Mol. Biol. 409, 439 (2011)]. We suggest experiments that will allow direct testing of the predicted effect.Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:41534238
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