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dc.contributor.authorCezar, Christine
dc.contributor.authorRoche, Ellen
dc.contributor.authorVandenburgh, Herman
dc.contributor.authorDuda, Georg
dc.contributor.authorWalsh, Conor
dc.contributor.authorMooney, David
dc.date.accessioned2019-10-11T12:29:06Z
dc.date.issued2016
dc.identifier.citationCezar, Christine A., Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda, Conor J. Walsh, and David J. Mooney. 2016. “Biologic-Free Mechanically Induced Muscle Regeneration.” Proceedings of the National Academy of Sciences113 (6): 1534–39. https://doi.org/10.1073/pnas.1517517113.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41534377*
dc.description.abstractSevere skeletal muscle injuries are common and can lead to extensive fibrosis, scarring, and loss of function. Clinically, no therapeutic intervention exists that allows for a full functional restoration. As a result, both drug and cellular therapies are being widely investigated for treatment of muscle injury. Because muscle is known to respond to mechanical loading, we investigated instead whether a material system capable of massage-like compressions could promote regeneration. Magnetic actuation of biphasic ferrogel scaffolds implanted at the site of muscle injury resulted in uniform cyclic compressions that led to reduced fibrous capsule formation around the implant, as well as reduced fibrosis and inflammation in the injured muscle. In contrast, no significant effect of ferrogel actuation on muscle vascularization or perfusion was found. Strikingly, ferrogel-driven mechanical compressions led to enhanced muscle regeneration and a similar to threefold increase inmaximum contractile force of the treated muscle at 2 wk compared with no-treatment controls. Although this study focuses on the repair of severely injured skeletal muscle, magnetically stimulated bioagent-free ferrogels may find broad utility in the field of regenerative medicine.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleBiologic-free mechanically induced muscle regeneration
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorMooney, David J.::00c54b0f354c5323ace343918ccde92e::600
dc.date.available2019-10-11T12:29:06Z
dash.workflow.comments1Science Serial ID 91324
dc.identifier.doi10.1073/pnas.1517517113
dash.source.volume113;6
dash.source.page1534


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