Selective advantage for conservative viruses
Shakhnovich, Eugene I.
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CitationBrumer, Yisroel, and Eugene I. Shakhnovich. 2005. “Selective Advantage for Conservative Viruses.” Physical Review E71 (3): 031903. https://doi.org/10.1103/PhysRevE.71.031903.
AbstractIn this article we study the full semiconservative treatment of a model for the coevolution of a virus and an adaptive immune system. Regions of viability are calculated for both conservatively and semiconservatively replicating viruses interacting with a realistic semiconservatively replicating immune system. The conservative virus is found to have a selective advantage in the form of an ability to survive in regions with a wider range of mutation rates than its semiconservative counterpart, as well as an increased replication rate where both species can survive. This may help explain the existence of a rich range of viruses with conservatively replicating genomes, a trait that is found nowhere else in nature.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41534504
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