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dc.contributor.authorPowell, Jennifer R.
dc.contributor.authorKim, Dennis H.
dc.contributor.authorAusubel, Frederick M.
dc.date.accessioned2019-10-12T13:15:52Z
dc.date.issued2009
dc.identifier.citationPowell, Jennifer R., Dennis H. Kim, and Frederick M. Ausubel. 2009. “The G Protein-Coupled Receptor FSHR-1 Is Required for the Caenorhabditis ElegansInnate Immune Response.” Proceedings of the National Academy of Sciences106 (8): 2782–87. doi:10.1073/pnas.0813048106.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41542693*
dc.description.abstractInnate immunity is an ancient defense system used by both vertebrates and invertebrates. Previously characterized innate immune responses in plants and animals are triggered by detection of pathogens using specific receptors, which typically use a leucine-rich repeat (LRR) domain to bind molecular patterns associated with infection. The nematode Caenorhabditis elegans uses defense pathways conserved with vertebrates; however, the mechanism by which C. elegans detects pathogens is unknown. We screened all LRR-containing transmembrane receptors in C. elegans and identified the G protein-coupled receptor FSHR-1 as an important component of the C. elegans immune response to Gram-negative and Gram-positive bacterial pathogens. FSHR-1 acts in the C. elegans intestine, the primary site of exposure to ingested pathogens. FSHR-1 signals in parallel to the known p38 MAPK pathway but converges to regulate the transcriptional induction of an overlapping but nonidentical set of antimicrobial effectors. FSHR-1 may act generally to boost the nematode immune response, or it may function as a pathogen receptor.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleThe G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorAusubel, Frederick M.::c9626aa032aeedd3e7e8858ac30832f4::600
dc.date.available2019-10-12T13:15:52Z
dash.workflow.comments1Science Serial ID 90468
dc.identifier.doi10.1073/pnas.0813048106
dash.source.volume106;8
dash.source.page2782


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