Co-Infection with Mycobacterium tuberculosis Impairs HIV-Specific CD8+ and CD4+ T Cell Functionality
Moosa, Mahomed-Yunus S.
Kasprowicz, Victoria O.
Paxton, William A.
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CitationChetty, Shivan, Pamla Govender, Jennifer Zupkosky, Mona Pillay, Musie Ghebremichael, Mahomed-Yunus S. Moosa, Thumbi Ndung’u, Filippos Porichis, and Victoria O. Kasprowicz. 2015. “Co-Infection with Mycobacterium Tuberculosis Impairs HIV-Specific CD8+ and CD4+ T Cell Functionality.” Edited by William A Paxton. PLOS ONE 10 (3): e0118654. doi:10.1371/journal.pone.0118654.
AbstractThe ability of antigen-specific T cells to simultaneously produce multiple cytokines is thought to correlate with the functional capacity and efficacy of T cells. These 'polyfunctional' T cells have been associated with control of HIV. We aimed to assess the impact of co-infection with Mycobacterium tuberculosis (MTB) on HIV-specific CD8+ and CD4+ T cell function. We assessed T cell functionality in 34 South African adults by investigating the IFN-gamma, IL-2, TNF-alpha, IL-21 and IL-17 cytokine secretion capacity, using polychromatic flow cytometry, following HIV Gag-specific stimulation of peripheral blood mononuclear cells. We show that MTB is associated with lower HIV-specific T cell function in co-infected as compared to HIV mono-infected individuals. This decline in function was greatest in co-infection with active Tuberculosis (TB) compared to co-infection with latent MTB (LTBI), suggesting that mycobacterial load may contribute to this loss of function. The described impact of MTB on HIV-specific T cell function may be a mechanism for increased HIV disease progression in co-infected subjects as functionally impaired T cells may be less able to control HIV.
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