Ultrahigh speed endoscopic optical coherence tomography for gastroenterology
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Author
Tsai, Tsung-Han
Lee, Hsiang-Chieh
Ahsen, Osman
Liang, Kaicheng
Giacomelli, Michael
Potsaid, Benjamin
Tao, Yuankai
Jayaraman, Vijaysekhar
Figueiredo, Marisa
Huang, Qin
Cable, Alex
Fujimoto, James
Mashimo, Hiroshi
Published Version
https://doi.org/10.1364/BOE.5.004387Metadata
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Tsai, Tsung-Han, Hsiang-Chieh Lee, Osman O. Ahsen, Kaicheng Liang, Michael G. Giacomelli, Benjamin M. Potsaid, Yuankai K. Tao, et al. 2014. “Ultrahigh Speed Endoscopic Optical Coherence Tomography for Gastroenterology.” Biomedical Optics Express 5 (12): 4387. doi:10.1364/BOE.5.004387.Abstract
We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 mu m axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 mu m spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging in the small intestine and the assessment of hiatal hernia using retroflex imaging. The high rotational scanning stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face OCT and cross-sectional imaging, as well as OCT angiography (OCTA) for 3D visualization of subsurface microvasculature. The ability to perform both structural and functional 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies and enhance the sensitivity and specificity of OCT for detecting pathology.Terms of Use
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