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dc.contributor.authorChen, Chi-Hua
dc.contributor.authorFiecas, Mark
dc.contributor.authorGutiérrez, E. D.
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorEyler, Lisa T.
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorThompson, Wesley K.
dc.contributor.authorFennema-Notestine, Christine
dc.contributor.authorHagler, Donald J. Jr.
dc.contributor.authorJernigan, Terry L.
dc.contributor.authorNeale, Michael C.
dc.contributor.authorFranz, Carol E.
dc.contributor.authorLyons, Michael J.
dc.contributor.authorFischl, Bruce
dc.contributor.authorTsuang, Ming T.
dc.contributor.authorDale, Anders M.
dc.contributor.authorKremen, William S.
dc.date.accessioned2019-10-13T16:02:43Z
dc.date.issued2013
dc.identifier.citationChen, C.-H., M. Fiecas, E. D. Gutierrez, M. S. Panizzon, L. T. Eyler, E. Vuoksimaa, W. K. Thompson, et al. 2013. “Genetic Topography of Brain Morphology.” Proceedings of the National Academy of Sciences 110 (42): 17089–94. doi:10.1073/pnas.1308091110.
dc.identifier.issn0027-8424
dc.identifier.issn0744-2831
dc.identifier.issn1091-6490
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41542753*
dc.description.abstractAnimal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an anterior-posterior axis using neuroimaging data of adult human twins. Here, we demonstrate differences in genetic influences on cortical thickness along a dorsal-ventral axis in the same cohort. The phenomenon of orthogonal gradations in cortical organization evident in different structural and functional properties may originate from genetic gradients. Another emerging theme of cortical patterning is that patterns of genetic influences recapitulate the spatial topography of the cortex within hemispheres. The genetic patterning of both cortical thickness and surface area corresponds to cortical functional specializations. Intriguingly, in contrast to broad similarities in genetic patterning, two sets of analyses distinguish cortical thickness and surface area genetically. First, genetic contributions to cortical thickness and surface area are largely distinct; there is very little genetic correlation (i.e., shared genetic influences) between them. Second, organizing principles among genetically defined regions differ between thickness and surface area. Examining the structure of the genetic similarity matrix among clusters revealed that, whereas surface area clusters showed great genetic proximity with clusters from the same lobe, thickness clusters appear to have close genetic relatedness with clusters that have similar maturational timing. The discrepancies are in line with evidence that the two traits follow different mechanisms in neurodevelopment. Our findings highlight the complexity of genetic influences on cortical morphology and provide a glimpse into emerging principles of genetic organization of the cortex.
dc.language.isoen_US
dc.publisherNational Academy of Sciences
dash.licenseLAA
dc.titleGenetic topography of brain morphology
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalProceedings of the National Academy of Sciences of the United States of America
dash.depositing.authorFischl, Bruce R.::4c276425513cbd84f55a89bf6b9ffe7e::600
dc.date.available2019-10-13T16:02:43Z
dash.workflow.comments1Science Serial ID 92937
dc.identifier.doi10.1073/pnas.1308091110
dash.source.volume110;42
dash.source.page17089


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