dc.contributor.author | Chand, Nikhilesh | |
dc.contributor.author | Clatworthy, Anne | |
dc.contributor.author | Hung, Deborah | |
dc.date.accessioned | 2019-10-13T16:02:50Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Chand, Nikhilesh S., Anne E. Clatworthy, and Deborah T. Hung. 2012. “The Two-Component Sensor KinB Acts as a Phosphatase To Regulate Pseudomonas Aeruginosa Virulence.” Journal of Bacteriology 194 (23): 6537–47. doi:10.1128/JB.01168-12. | |
dc.identifier.issn | 0021-9193 | |
dc.identifier.issn | 1067-8832 | |
dc.identifier.issn | 1098-5530 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41542758 | * |
dc.description.abstract | Pseudomonas aeruginosa is an opportunistic pathogen that is capable of causing both acute and chronic infections. P. aeruginosa virulence is subject to sophisticated regulatory control by two-component systems that enable it to sense and respond to environmental stimuli. We recently reported that the two-component sensor KinB regulates virulence in acute P. aeruginosa infection. Furthermore, it regulates acute-virulence-associated phenotypes such as pyocyanin production, elastase production, and motility in a manner independent of its kinase activity. Here we show that KinB regulates virulence through the global sigma factor AlgU, which plays a key role in repressing P. aeruginosa acute-virulence factors, and through its cognate response regulator AlgB. However, we show that rather than phosphorylating AlgB, KinB's primary role in the regulation of virulence is to act as a phosphatase to dephosphorylate AlgB and alleviate phosphorylated AlgB's repression of acute virulence. | |
dc.language.iso | en_US | |
dc.publisher | American Society for Microbiology | |
dash.license | LAA | |
dc.title | The Two-Component Sensor KinB Acts as a Phosphatase to Regulate Pseudomonas aeruginosa Virulence | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | Journal of Bacteriology | |
dash.depositing.author | Hung, Deborah Tan::45968263d9ae67f8c1970987265073e7::600 | |
dc.date.available | 2019-10-13T16:02:50Z | |
dash.workflow.comments | 1Science Serial ID 51164 | |
dc.identifier.doi | 10.1128/JB.01168-12 | |
dash.source.volume | 194;23 | |
dash.source.page | 6537 | |