Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem
Schmidt, Aaron G.
Yang, Priscilla L.
Harrison, Stephen C.
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CitationSchmidt, A. G., P. L. Yang, and S. C. Harrison. 2010. “Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem.” Journal of Virology 84 (24): 12549–54. doi:10.1128/JVI.01440-10.
AbstractPeptides derived from the "stem" of dengue virus (DV) type 2 (DV2) envelope (E) protein inhibit DV2 infectivity, targeting a late-stage fusion intermediate. We show here that stem peptides from all DV serotypes cross-inhibit DV1 to DV4 but that corresponding peptides derived from related flaviviruses do not. This failure to inhibit infection is not due to poor interaction with the E protein but rather to loss of association with the virion membrane. Residues 442 to 444 of the stem are determinants of inhibition; increasing hydrophobicity in this region increases inhibitory strength. These results support a two-step model of how stem-derived peptides inhibit viral entry.
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