| dc.contributor.author | Schmidt, Aaron G. | |
| dc.contributor.author | Yang, Priscilla L. | |
| dc.contributor.author | Harrison, Stephen C. | |
| dc.date.accessioned | 2019-10-13T16:03:12Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Schmidt, A. G., P. L. Yang, and S. C. Harrison. 2010. “Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem.” Journal of Virology 84 (24): 12549–54. doi:10.1128/JVI.01440-10. | |
| dc.identifier.issn | 0022-538X | |
| dc.identifier.issn | 1070-6321 | |
| dc.identifier.issn | 1098-5514 | |
| dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41542784 | * |
| dc.description.abstract | Peptides derived from the "stem" of dengue virus (DV) type 2 (DV2) envelope (E) protein inhibit DV2 infectivity, targeting a late-stage fusion intermediate. We show here that stem peptides from all DV serotypes cross-inhibit DV1 to DV4 but that corresponding peptides derived from related flaviviruses do not. This failure to inhibit infection is not due to poor interaction with the E protein but rather to loss of association with the virion membrane. Residues 442 to 444 of the stem are determinants of inhibition; increasing hydrophobicity in this region increases inhibitory strength. These results support a two-step model of how stem-derived peptides inhibit viral entry. | |
| dc.language.iso | en_US | |
| dc.publisher | American Society for Microbiology | |
| dash.license | LAA | |
| dc.title | Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem | |
| dc.type | Journal Article | |
| dc.description.version | Version of Record | |
| dc.relation.journal | Journal of Virology | |
| dash.depositing.author | Harrison, Stephen::29356e859c6d3698df98e8184352069e::600 | |
| dc.date.available | 2019-10-13T16:03:12Z | |
| dash.workflow.comments | 1Science Serial ID 65591 | |
| dc.identifier.doi | 10.1128/JVI.01440-10 | |
| dash.source.volume | 84;24 | |
| dash.source.page | 12549 | |
