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dc.contributor.authorSchmidt, Aaron G.
dc.contributor.authorYang, Priscilla L.
dc.contributor.authorHarrison, Stephen C.
dc.date.accessioned2019-10-13T16:03:12Z
dc.date.issued2010
dc.identifier.citationSchmidt, A. G., P. L. Yang, and S. C. Harrison. 2010. “Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem.” Journal of Virology 84 (24): 12549–54. doi:10.1128/JVI.01440-10.
dc.identifier.issn0022-538X
dc.identifier.issn1070-6321
dc.identifier.issn1098-5514
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41542784*
dc.description.abstractPeptides derived from the "stem" of dengue virus (DV) type 2 (DV2) envelope (E) protein inhibit DV2 infectivity, targeting a late-stage fusion intermediate. We show here that stem peptides from all DV serotypes cross-inhibit DV1 to DV4 but that corresponding peptides derived from related flaviviruses do not. This failure to inhibit infection is not due to poor interaction with the E protein but rather to loss of association with the virion membrane. Residues 442 to 444 of the stem are determinants of inhibition; increasing hydrophobicity in this region increases inhibitory strength. These results support a two-step model of how stem-derived peptides inhibit viral entry.
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dash.licenseLAA
dc.titlePeptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalJournal of Virology
dash.depositing.authorHarrison, Stephen::29356e859c6d3698df98e8184352069e::600
dc.date.available2019-10-13T16:03:12Z
dash.workflow.comments1Science Serial ID 65591
dc.identifier.doi10.1128/JVI.01440-10
dash.source.volume84;24
dash.source.page12549


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