Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus
Collier, R. John
Park, Jin Mo
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CitationKim, C., S. Wilcox-Adelman, Y. Sano, W.-J. Tang, R. J. Collier, and J. M. Park. 2008. “Antiinflammatory CAMP Signaling and Cell Migration Genes Co-Opted by the Anthrax Bacillus.” Proceedings of the National Academy of Sciences 105 (16): 6150–55. doi:10.1073/pnas.0800105105.
AbstractBacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of vascular endothelial growth factor. The transcription factor CREB and the syndecan-1 gene, a CREB target, play crucial roles in ET-induced macrophage migration. These molecular and cellular responses occur in macrophages engaged in antiinflammatory G protein-coupled receptor activation, thus illustrating a common signaling circuitry controlling resolution of inflammation and host cell hijacking by B. anthracis.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41543013
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