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dc.contributor.authorHandschin, Christoph
dc.contributor.authorChin, Sherry
dc.contributor.authorLi, Ping
dc.contributor.authorLiu, Fenfen
dc.contributor.authorMaratos-Flier, Eleftheria
dc.contributor.authorLeBrasseur, Nathan K.
dc.contributor.authorYan, Zhen
dc.contributor.authorSpiegelman, Bruce M.
dc.date.accessioned2019-10-14T16:31:40Z
dc.date.issued2007
dc.identifier.citationHandschin, Christoph, Sherry Chin, Ping Li, Fenfen Liu, Eleftheria Maratos-Flier, Nathan K. LeBrasseur, Zhen Yan, and Bruce M. Spiegelman. 2007. “Skeletal Muscle Fiber-Type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-Specific Knock-out Animals.” Journal of Biological Chemistry 282 (41): 30014–21. doi:10.1074/jbc.M704817200.
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41543093*
dc.description.abstractThe transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression of PGC-1 alpha in muscle results in increased mitochondrial number and function as well as an increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1 alpha knock-out mice have a very complex phenotype but do not have a marked skeletal muscle phenotype. We thus analyzed skeletal muscle-specific PGC-1 alpha knock-out mice to identify a specific role for PGC-1 alpha in skeletal muscle function. These mice exhibit a shift from oxidative type I and IIa toward type IIx and IIb muscle fibers. Moreover, skeletal muscle-specific PGC-1 alpha knock-out animals have reduced endurance capacity and exhibit fiber damage and elevated markers of inflammation following treadmill running. Our data demonstrate a critical role for PGC-1 alpha in maintenance of normal fiber type composition and of muscle fiber integrity following exertion.
dc.language.isoen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dash.licenseLAA
dc.titleSkeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalThe Journal of Biological Chemistry
dash.depositing.authorSpiegelman, Bruce Michael::f9a398ba9e863d3c5891a01e9cb89f0b::600
dc.date.available2019-10-14T16:31:40Z
dash.workflow.comments1Science Serial ID 106470
dc.identifier.doi10.1074/jbc.M704817200
dash.source.volume282;41
dash.source.page30014-30021


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