dc.contributor.author | Manor, Brad | |
dc.contributor.author | Zhou, Junhong | |
dc.contributor.author | Jor'dan, Azizah | |
dc.contributor.author | Zhang, Jue | |
dc.contributor.author | Fang, Jing | |
dc.contributor.author | Pascual-Leone, Alvaro | |
dc.date.accessioned | 2019-10-14T16:32:01Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Manor, Brad, Junhong Zhou, Azizah Jor’dan, Jue Zhang, Jing Fang, and Alvaro Pascual-Leone. 2016. “Reduction of Dual-Task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders.” Journal of Cognitive Neuroscience 28 (2): 275–81. doi:10.1162/jocn_a_00897. | |
dc.identifier.issn | 0898-929X | |
dc.identifier.issn | 1530-8898 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41543117 | * |
dc.description.abstract | Dual tasking (e.g., walking or standing while performing a cognitive task) disrupts performance in one or both tasks, and such dual-task costs increase with aging into senescence. Dual tasking activates a network of brain regions including pFC. We therefore hypothesized that facilitation of prefrontal cortical activity via transcranial direct current stimulation (tDCS) would reduce dual-task costs in older adults. Thirty-seven healthy older adults completed two visits during which dual tasking was assessed before and after 20 min of real or sham tDCS targeting the left pFC. Trials of single-task standing, walking, and verbalized serial subtractions were completed, along with dual-task trials of standing or walking while performing serial subtractions. Dual-task costs were calculated as the percent change in markers of gait and postural control and serial subtraction performance, from single to dual tasking. Significant dual-task costs to standing, walking, and serial subtraction performance were observed before tDCS (p < .01). These dual-task costs were less after real tDCS as compared with sham tDCS as well as compared with either pre-tDCS condition (p < .03). Further analyses indicated that tDCS did not alter single task performance but instead improved performance solely within dual-task conditions (p < .02). These results demonstrate that dual tasking can be improved by modulating prefrontal activity, thus indicating that dual-task decrements are modifiable and may not necessarily reflect an obligatory consequence of aging. Moreover, tDCS may ultimately serve as a novel approach to preserving dual-task capacity into senescence. | |
dc.language.iso | en_US | |
dc.publisher | Massachusetts Institute of Technology Press (MIT Press) | |
dash.license | OAP | |
dc.title | Reduction of Dual-task Costs by Noninvasive Modulation of Prefrontal Activity in Healthy Elders | |
dc.type | Journal Article | |
dc.description.version | Accepted Manuscript | |
dc.relation.journal | Journal of Cognitive Neuroscience | |
dash.depositing.author | Pascual-Leone, Alvaro::c20607211caf9c90e22a3c0ec836ca53::600 | |
dc.date.available | 2019-10-14T16:32:01Z | |
dash.workflow.comments | 1Science Serial ID 50647 | |
dc.identifier.doi | 10.1162/jocn_a_00897 | |
dash.source.volume | 28;2 | |
dash.source.page | 275 | |