Patient-oriented gene set analysis for cancer mutation data
Boca, Simina M.
Kinzler, Kenneth W.
Velculescu, Victor E.
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CitationBoca, Simina M, Kenneth W Kinzler, Victor E Velculescu, Bert Vogelstein, and Giovanni Parmigiani. 2010. “Patient-Oriented Gene Set Analysis for Cancer Mutation Data.” Genome Biology 11 (11): R112. https://doi.org/10.1186/gb-2010-11-11-r112.
AbstractRecent research has revealed complex heterogeneous genomic landscapes in human cancers. However, mutations tend to occur within a core group of pathways and biological processes that can be grouped into gene sets. To better understand the significance of these pathways, we have developed an approach that initially scores each gene set at the patient rather than the gene level. In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41552030
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