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dc.contributor.authorBuckner, Randy
dc.contributor.authorDiNicola, Lauren
dc.date.accessioned2019-11-20T14:20:46Z
dc.date.issued2019-09-06
dc.identifier.citationBuckner, Randy L., and Lauren M. DiNicola. 2019. The Brain's Default Network: Updated Anatomy, Physiology and Evolving Insights. Nature Reviews Neuroscience 20, no. 10: 593-608.en_US
dc.identifier.issn1471-003Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41875422*
dc.description.abstractDiscoveries over the past two decades demonstrate that regions distributed throughout association cortex, often called the default network, are suppressed during tasks that demand external attention and are active during remembering, envisioning the future and making social inferences. This Review describes progress in understanding the organization and function of networks embedded within these association regions. Detailed high-resolution analyses of individuals suggest that the default network is not a single network, as historically described, but instead comprises multiple interwoven networks. The multiple networks share a common organizational motif (also evident in marmoset and macaque anatomical circuits) that may support a general class of processing function dependent on internally- constructed rather than externally-constrained representations, with each separate interwoven network specialized for a distinct processing domain. Direct neuronal recordings in humans and monkeys reveal evidence for competitive relations between the internally- and externally-oriented networks. Findings from rodent studies suggest that the thalamus might be essential to controlling which networks are engaged through specialized thalamic reticular neurons, including antagonistic subpopulations. These association networks (and presumably thalamocortical circuits) are expanded in the human and may be particularly vulnerable to dysregulation implicated in mental illness.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relationNature Reviews Neuroscienceen_US
dc.relation.isversionofdoi: 10.1038/s41583-019-0212-7en_US
dash.licenseMETA_ONLY
dc.titleThe Brain's Default Network: Updated Anatomy, Physiology, and Evolving Insightsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalNature Reviews Neuroscienceen_US
dash.depositing.authorBuckner, Randy
dash.waiver2019-07-12
dc.date.available2019-11-20T14:20:46Z
dash.affiliation.otherFaculty of Arts & Sciencesen_US
dash.funder.nameNational Science Foundationen_US
dash.funder.nameNational Institutes of Healthen_US
dash.funder.awardP50MH106435en_US
dash.funder.awardDGE1745303en_US
dc.identifier.doi10.1038/s41583-019-0212-7*
dash.waiver.reasonRequired for publication in Nature Reviews Neuroscienceen_US
dash.contributor.affiliatedDiNicola, Lauren
dash.contributor.affiliatedBuckner, Randy


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