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dc.contributor.authorKossowsky, Joe
dc.date.accessioned2019-11-27T09:07:23Z
dc.date.created2017-05
dc.date.issued2017-06-19
dc.date.submitted2017
dc.identifier.citationKossowsky, Joe. 2017. Association Between Genetic Variants and Clinical Features Among Sub-Classes of Migraine and Probable Migraine. Master's thesis, Harvard Medical School.
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41940986*
dc.description.abstractMigraine is a prevalent and disabling neurological disease, characterized by substantial clinical heterogeneity. The current study examined 46 single nucleotide polymorphisms (SNPs) recently identified in a meta-analysis of genome-wide association studies for association with migraine. Using a likelihood framework approach and application of latent class methodology, we explore the selective association of these SNPs with individual symptoms and possible substructures in the Women’s Genome Health Study, a large population-based cohort of women, including 3,003 active migraineurs and 18,108 controls without migraine. We identified 15 SNPs indicating 12 loci with significant preferential associations with migraine features, six of which were previously unreported. Our findings reflect the multifactorial pathophysiology underlying migraine and highlight the importance of assessing and understanding the selective genetic association with the individual features, as they may indicate diverse yet related biological pathways that are not induced by diagnostic criteria. This deeper and differentiated understanding of migraine can form the foundation for a personalized therapeutic approach with much greater precision.
dc.description.sponsorshipMaster of Medical Sciences in Biomedical Informatics
dc.format.mimetypeapplication/pdf
dc.language.isoen
dash.licenseLAA
dc.subjectMigraine
dc.subjectGWAS
dc.subjectPhenotyping
dc.subjectLatent Class Analysis
dc.titleAssociation Between Genetic Variants and Clinical Features Among Sub-Classes of Migraine and Probable Migraine
dc.typeThesis or Dissertation
dash.depositing.authorKossowsky, Joe
dc.date.available2019-11-27T09:07:23Z
thesis.degree.date2017
thesis.degree.grantorHarvard Medical School
thesis.degree.grantorHarvard Medical School
thesis.degree.levelMasters
thesis.degree.levelMasters
thesis.degree.nameMaster of Medical Sciences
thesis.degree.nameMaster of Medical Sciences
dc.contributor.committeeMemberMandl, Kenneth D.
dc.contributor.committeeMemberReis, Ben
dc.contributor.committeeMemberChasman, Daniel I.
dc.type.materialtext
dash.identifier.vireo
dc.identifier.orcid0000-0002-6272-6259
dash.author.emailjoeykossowsky@gmail.com


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