The Gain Paradox

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The Gain Paradox

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Title: The Gain Paradox
Author: Berg, Howard
Citation: Berg, Howard Curtis. 2009. The gain paradox. Progress in Biophysics and Molecular Biology 100(1-3): 2-3.
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Abstract: Chemoreceptors in Escherichia coli control the activity of a kinase that phosphorylates a response regulator that, in turn, biases the direction of rotation of flagellar motors, affecting the manner in which cells swim. A small change in receptor occupancy induces a large change in kinase activity. This gain is generated by allosteric interactions between receptors, which are arranged in clusters. The idea that such amplification might occur was advanced by [Bray et al., 1998] and [Bray, 2002].
Published Version: doi:10.1016/j.pbiomolbio.2009.06.001
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