The Gain Paradox
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CitationBerg, Howard Curtis. 2009. The gain paradox. Progress in Biophysics and Molecular Biology 100(1-3): 2-3.
AbstractChemoreceptors in Escherichia coli control the activity of a kinase that phosphorylates a response regulator that, in turn, biases the direction of rotation of flagellar motors, affecting the manner in which cells swim. A small change in receptor occupancy induces a large change in kinase activity. This gain is generated by allosteric interactions between receptors, which are arranged in clusters. The idea that such amplification might occur was advanced by [Bray et al., 1998] and [Bray, 2002].
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