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dc.contributor.authorLipsitch, Marc
dc.contributor.authorGoldstein, Edward
dc.contributor.authorRay, G. Thomas
dc.contributor.authorFireman, Bruce
dc.date.accessioned2020-03-25T16:47:04Z
dc.date.issued2019-08-12
dc.identifier.citationLipsitch, M., Goldstein, E., Ray, G., & Fireman, B. (2019). Depletion-of-susceptibles bias in influenza vaccine waning studies: How to ensure robust results. Epidemiology and Infection, 147, E306. doi:10.1017/S0950268819001961en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:42639311*
dc.description.abstractVaccine effectiveness (VE) studies are subject to biases due to depletion of at-risk persons or of highly susceptible persons at different rates from different groups (depletion-of-susceptibles bias), a problem that can also lead to biased estimates of waning effectiveness, including spurious inference of waning when none exists. An alternative study design to identify waning is to study only vaccinated persons, and compare for each day the incidence in persons with earlier or later dates of vaccination. Prior studies suggested under what conditions this alternative would yield correct estimates of waning. Here we define the depletion-of-susceptibles process formally and show mathematically that for influenza vaccine waning studies, a randomized trial or corresponding observational study that compares incidence at a specific calendar time among individuals vaccinated at different times before the influenza season begins will not be vulnerable depletion-of-susceptibles bias in its inference of waning under the null hypothesis that none exists, and will - if waning does actually occur - underestimate the extent of waning. Such a design is thus robust in the sense that a finding of waning in that inference framework reflects actual waning of vaccine-induced immunity. We recommend such a design for future studies of waning, whether observational or randomized.en_US
dc.language.isoen_USen_US
dc.publisherCambridge University Pressen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003633/en_US
dash.licenseLAA
dc.subjectinfluenzaen_US
dc.subjectvaccineen_US
dc.titleDepletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust resultsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEpidemiology and Infectionen_US
dc.date.available2020-03-25T16:47:04Z
dc.identifier.doi10.1101/19003616
dash.contributor.affiliatedGoldstein, Edward
dash.contributor.affiliatedLipsitch, Marc


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