Comparative genomics and transcriptomics of host–pathogen interactions in insects: evolutionary insights and future directions
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CitationSackton, Timothy B. "Comparative Genomics and Transcriptomics of Host-pathogen Interactions in Insects: Evolutionary Insights and Future Directions." Current Opinion in Insect Science 31 (2018): 106-113.
AbstractClassical evolutionary studies of protein-coding genes have established that genes in the canonical immune system are often among the most rapidly evolving within and between species. As more genomes and transcriptomes across insects are sequenced, it is becoming clear that duplications and losses of immune genes are also a likely consequence of host-pathogen interactions. Furthermore, particular species respond to diverse pathogenic challenges with a wide range of challenge-specific responses that are still poorly understood. Transcriptional studies, using RNA-seq to characterize the infection-regulated transcriptome of diverse insects, are crucial for additional progress in understanding the ecology and evolution of the full complexity of the host response.
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