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dc.contributor.authorAdam, Yoav
dc.contributor.authorKim, Jeong J.
dc.contributor.authorLou, Shan
dc.contributor.authorZhao, Yongxin
dc.contributor.authorXie, Michael E.
dc.contributor.authorBrinks, Daan
dc.contributor.authorWu, Hao
dc.contributor.authorMostajo-Radji, Mohammed A.
dc.contributor.authorKheifets, Simon
dc.contributor.authorParot, Vicente
dc.contributor.authorChettih, Selmaan
dc.contributor.authorWilliams, Katherine J.
dc.contributor.authorGmeiner, Benjamin
dc.contributor.authorFarhi, Samouil L.
dc.contributor.authorMadisen, Linda
dc.contributor.authorBuchanan, E. Kelly
dc.contributor.authorKinsella, Ian
dc.contributor.authorZhou, Ding
dc.contributor.authorPaninski, Liam
dc.contributor.authorHarvey, Christopher D.
dc.contributor.authorZeng, Hongkui
dc.contributor.authorArlotta, Paola
dc.contributor.authorCampbell, Robert E.
dc.contributor.authorCohen, Adam
dc.date.accessioned2020-04-09T16:04:43Z
dc.date.issued2019-05
dc.identifier.citationAdam, Y., Kim, J.J., Lou, S. et al. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics. Nature 569, 413–417 (2019). https://doi.org/10.1038/s41586-019-1166-7en_US
dc.identifier.issn0028-0836en_US
dc.identifier.issn1476-4687en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:42658795*
dc.description.abstractA technology to record membrane potential from multiple neurons, simultaneously, in behaving animals will have a transformative impact on neuroscience research1, 2. Genetically encoded voltage indicators are a promising tool for these purposes, but were so far limited to single-cell recordings with marginal signal to noise ratio (SNR) in vivo3-5. We developed improved near infrared voltage indicators, high speed microscopes and targeted gene expression schemes which enabled recordings of supra- and subthreshold voltage dynamics from multiple neurons simultaneously in mouse hippocampus, in vivo. The reporters revealed sub-cellular details of back-propagating action potentials and correlations in sub-threshold voltage between multiple cells. In combination with optogenetic stimulation, the reporters revealed brain state-dependent changes in neuronal excitability, reflecting the interplay of excitatory and inhibitory synaptic inputs. These tools open the possibility for detailed explorations of network dynamics in the context of behavior.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relationNatureen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613938/en_US
dash.licenseLAA
dc.subjectMultidisciplinaryen_US
dc.titleVoltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamicsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dash.waiver2019-01-01
dc.date.available2020-04-09T16:04:43Z
dash.affiliation.otherFaculty of Arts & Sciencesen_US
dc.identifier.doi10.1038/s41586-019-1166-7
dc.source.journalNature
dash.waiver.reasonRequired by publisher.en_US
dash.source.volume569;7756
dash.source.page413-417
dash.contributor.affiliatedCohen, Adam


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