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dc.contributor.authorNorden, A. D.
dc.contributor.authorLigon, Keith Lloyd
dc.contributor.authorHammond, Samantha N.
dc.contributor.authorMuzikansky, A.
dc.contributor.authorReardon, David Allen
dc.contributor.authorKaley, Thomas J.
dc.contributor.authorBatchelor, Tracy Todd
dc.contributor.authorPlotkin, Scott
dc.contributor.authorRaizer, Jeffrey J.
dc.contributor.authorWong, Eric T.
dc.contributor.authorDrappatz, Jan
dc.contributor.authorLesser, Glenn J.
dc.contributor.authorHaidar, Sam
dc.contributor.authorBeroukhim, Rameen
dc.contributor.authorLee, Eudocia Quant
dc.contributor.authorDoherty, Lisa
dc.contributor.authorLafrankie, Debra
dc.contributor.authorGaffey, S. C.
dc.contributor.authorGerard, Mary
dc.contributor.authorSmith, Katrina H.
dc.contributor.authorMcCluskey, C.
dc.contributor.authorPhuphanich, Surasak
dc.contributor.authorWen, Patrick Yung Chih
dc.date.accessioned2020-04-28T11:57:50Z
dc.date.issued2014
dc.identifierQuick submit: 2017-04-22T20:04:45-0400
dc.identifier.citationNorden, A. D., K. L. Ligon, S. N. Hammond, A. Muzikansky, D. A. Reardon, T. J. Kaley, T. T. Batchelor, et al. 2014. Phase II Study of Monthly Pasireotide LAR (SOM230C) for Recurrent or Progressive Meningioma. Neurology 84, no. 3: 280–286.en_US
dc.identifier.issn0028-3878en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:42661838*
dc.description.abstractObjective: A subset of meningiomas recur after surgery and radiation therapy, but no medical therapy for recurrent meningioma has proven effective. Methods: Pasireotide LAR is a long-acting somatostatin analog that may inhibit meningioma growth. This was a phase II trial in patients with histologically confirmed recurrent or progressive meningioma designed to evaluate whether pasireotide LAR prolongs progression-free survival at 6 months (PFS6). Patients were stratified by histology (atypical [World Health Organization grade 2] and malignant [grade 3] meningiomas in cohort A and benign [grade 3] in cohort B). Results: Eighteen patients were accrued in cohort A and 16 in cohort B. Cohort A had median age 59 years, median Karnofsky performance status 80, 17 (94%) had previous radiation therapy, and 11 (61%) showed high octreotide uptake. Cohort B had median age 52 years, median Karnofsky performance status 90, 11 (69%) had previous radiation therapy, and 12 (75%) showed high octreotide uptake. There were no radiographic responses to pasireotide LAR therapy in either cohort. Twelve patients (67%) in cohort A and 13 (81%) in cohort B achieved stable disease. In cohort A, PFS6 was 17% and median PFS 15 weeks (95% confidence interval: 8–20). In cohort B, PFS6 was 50% and median PFS 26 weeks (12–43). Treatment was well tolerated. Octreotide uptake and insulin-like growth factor–1 levels did not predict outcome. Expression of somatostatin receptor 3 predicted favorable PFS and overall survival. Conclusions: Pasireotide LAR has limited activity in recurrent meningiomas. The finding that somatostatin receptor 3 is associated with favorable outcomes warrants further investigation. Classification of evidence: This study provides Class IV evidence that in patients with recurrent or progressive meningioma, pasireotide LAR does not significantly increase the proportion of patients with PFS at 6 months.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1212/WNL.0000000000001153en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335993/en_US
dash.licenseMETA_ONLY
dash.licenseMETA_ONLY
dc.titlePhase II Study of Monthly Pasireotide LAR (SOM230C) for Recurrent or Progressive Meningiomaen_US
dc.typeJournal Articleen_US
dc.date.updated2017-04-23T00:04:37Z
dc.description.versionVersion of Recorden_US
dc.relation.journalNeurologyen_US
dash.depositing.authorPlotkin, Scott
dc.date.available2015
dc.date.available2020-04-28T11:57:50Z
dc.identifier.doi10.1212/WNL.0000000000001153*
dash.contributor.affiliatedLee, Eudocia
dash.contributor.affiliatedReardon, David
dash.contributor.affiliatedBatchelor, Tracy
dash.contributor.affiliatedWong, Eric
dash.contributor.affiliatedWen, Patrick
dash.contributor.affiliatedPlotkin, Scott
dash.contributor.affiliatedBeroukhim, Rameen
dash.contributor.affiliatedLigon, Keith


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