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dc.contributor.authorKhabbaz, Kamal
dc.contributor.authorMahmood, Feroze-Ud-Den
dc.contributor.authorShakil, Omair
dc.contributor.authorWarraich, Haider J.
dc.contributor.authorGorman, Joseph H.
dc.contributor.authorGorman, Robert C.
dc.contributor.authorMatyal, Robina
dc.contributor.authorPanzica, Peter J.
dc.contributor.authorHess, Philip E.
dc.date.accessioned2020-05-04T09:49:01Z
dc.date.issued2013
dc.identifierQuick submit: 2017-04-19T23:04:39-0400
dc.identifier.citationKhabbaz, Kamal R., Feroze Mahmood, Omair Shakil, Haider J. Warraich, Joseph H. Gorman, Robert C. Gorman, Robina Matyal, Peter Panzica, and Philip E. Hess. 2013. Dynamic 3-Dimensional Echocardiographic Assessment of Mitral Annular Geometry in Patients With Functional Mitral Regurgitation. The Annals of Thoracic Surgery 95, no. 1: 105–110.en_US
dc.identifier.issn0003-4975en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:42663145*
dc.description.abstractBackground: Mitral valve (MV) annular dynamics have been well described in animal models of functional mitral regurgitation (FMR). Despite this little, if any, data exists regarding the dynamic MV annular geometry in humans with FMR. In the current study we hypothesized that three-dimensional (3D) echocardiography, in conjunction with commercially available software, could be used to quantify the dynamic changes in MV annular geometry associated with FMR. Methods: Intraoperative 3D transesophageal echocardiographic data obtained from 34 patients with FMR and 15 controls undergoing cardiac surgery were dynamically analyzed for differences in mitral annular geometry with TomTec© 4D MV Assessment 2.0 software. Results: In patients with FMR, the mean mitral annular area (14.6cm2 vs. 9.6cm2), circumference (14.1cm vs. 11.4 cm), anteroposterior (4.0cm vs. 3.0cm) and anterolateral-posteromedial (4.3cm vs. 3.6cm) diameters, tenting volume (6.2mm3 vs. 3.5mm3) and nonplanarity angle (154° ± 15 vs. 136° ± 11) were greater at all points during systole compared to controls (p<0.01). Vertical mitral annular displacement (5.8mm vs. 8.3mm) was reduced in FMR compared to controls (p<0.01). Conclusions: There are significant differences in dynamic mitral annular geometry between patients with and without FMR. We were able to analyze these changes in a clinically feasible fashion. Ready availability of this information has the potential to aid comprehensive quantification of mitral annular function and possibly assist in both clinical decision-making and annuloplasty ring selection.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.athoracsur.2012.08.078en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228313/en_US
dash.licenseMETA_ONLY
dash.licenseOAP
dc.subjectMitral regurgitationen_US
dc.subjectechocardiographyen_US
dc.titleDynamic 3-Dimensional Echocardiographic Assessment of Mitral Annular Geometry in Patients With Functional Mitral Regurgitationen_US
dc.typeJournal Articleen_US
dc.date.updated2017-04-20T03:04:30Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalThe Annals of Thoracic Surgeryen_US
dash.depositing.authorKhabbaz, Kamal
dc.date.available2013
dc.date.available2020-05-04T09:49:01Z
dc.identifier.doi10.1016/j.athoracsur.2012.08.078*
dash.contributor.affiliatedShakil, Omair
dash.contributor.affiliatedPanzica, Peter
dash.contributor.affiliatedMahmood, Feroze-Ud-Den
dash.contributor.affiliatedKhabbaz, Kamal
dash.contributor.affiliatedHess, Philip
dash.contributor.affiliatedMatyal, Robina


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