dc.contributor.author | Aschard, Hugues | |
dc.contributor.author | Franks, Paul | |
dc.date.accessioned | 2020-05-05T14:25:59Z | |
dc.identifier.citation | Bentley, A.R., Sung, Y.J., Brown, M.R. et al. Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet 51, 636–648 (2019). https://doi.org/10.1038/s41588-019-0378-y | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:42663641 | * |
dc.description.abstract | The concentrations of high- and low-density lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 novel loci, some of which were detected only because the association differed by smoking status. Additionally, we demonstrated the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation | Nature Communications | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pubmed/30926973 | en_US |
dash.license | LAA | |
dc.title | Multi-ancestry genome-wide smoking interaction study of 387,272 individuals identifies novel lipid loci | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Nature Genetics | en_US |
dash.depositing.author | Aschard, Hugues | |
dash.waiver | 2018-12-07 | |
dc.date.available | 2020-05-05T14:25:59Z | |
dash.affiliation.other | Harvard T.H. Chan School of Public Health | en_US |
dash.workflow.comments | Forthcoming.
Main article has track changes, others may also.
Articles, ppt, and excel file need to be converted to PDF. | en_US |
dash.waiver.reason | An article from some colleagues has been accepted for publication in Nature Communications. The editor request an open access policy waiver before proceeding to publication | en_US |
dash.contributor.affiliated | Aschard, Hugues | |
dash.contributor.affiliated | Franks, Paul | |