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dc.contributor.authorThunnissen, Erik
dc.contributor.authorBeasley, Mary Beth
dc.contributor.authorBorczuk, Alain C
dc.contributor.authorBrambilla, Elisabeth
dc.contributor.authorChirieac, Lucian
dc.contributor.authorDacic, Sanja
dc.contributor.authorFlieder, Douglas
dc.contributor.authorGazdar, Adi
dc.contributor.authorGeisinger, Kim
dc.contributor.authorHasleton, Philip
dc.contributor.authorIshikawa, Yuichi
dc.contributor.authorKerr, Keith M
dc.contributor.authorLantejoul, Sylvie
dc.contributor.authorMatsuno, Yoshiro
dc.contributor.authorMinami, Yuko
dc.contributor.authorMoreira, Andre L
dc.contributor.authorMotoi, Noriko
dc.contributor.authorNicholson, Andrew G
dc.contributor.authorNoguchi, Masayuki
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorPelosi, Giuseppe
dc.contributor.authorPetersen, Iver
dc.contributor.authorRekhtman, Natasha
dc.contributor.authorRoggli, Victor
dc.contributor.authorTravis, William D
dc.contributor.authorTsao, Ming S
dc.contributor.authorWistuba, Ignacio
dc.contributor.authorXu, Haodong
dc.contributor.authorYatabe, Yasushi
dc.contributor.authorZakowski, Maureen
dc.contributor.authorWitte, Birgit
dc.contributor.authorKuik, Dirk Joop
dc.date.accessioned2020-05-21T16:09:01Z
dc.date.issued2012-07-20
dc.identifierQuick submit: 2017-09-22T09:16:12-0400
dc.identifier.citationThunnissen, Erik, Mary Beth Beasley, Alain C Borczuk, Elisabeth Brambilla, Lucian R Chirieac, et al. "Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma." Mod Pathol 25 (2012): 1574–1583.en_US
dc.identifier.issn0893-3952en_US
dc.identifier.issn1530-0285en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:42668606*
dc.description.abstractHistological subtyping of pulmonary adenocarcinoma has recently been updated based on predominant pattern, but data on reproducibility are required for validation. This study first assesses reproducibility in subtyping adenocarcinomas and then assesses further the distinction between invasive and non-invasive (wholly lepidic) pattern of adenocarcinoma, among an international group of pulmonary pathologists. Two ring studies were performed using a micro-photographic image-based method, evaluating selected images of lung adenocarcinoma histologic patterns. In the first study, 26 pathologists reviewed representative images of typical and ‘difficult’ histologic patterns. A total number of scores for the typical patterns combined (n = 94) and the difficult cases (n = 21) were 2444 and 546, respectively. The mean kappa score (± s.d.) for the five typical patterns combined and for difficult cases were 0.77 ± 0.07 and 0.38 ± 0.14, respectively. Although 70% of the observers identified 12–65% of typical images as single pattern, highest for solid and least for micropapillary, recognizing the predominant pattern was achieved in 92–100%, of the images except for micropapillary pattern (62%). For the second study on invasion, identified as a key problem area from the first study, 28 pathologists submitted and reviewed 64 images representing typical as well as ‘difficult’ examples. The kappa for typical and difficult cases was 0.55 ± 0.06 and 0.08 ± 0.02, respectively, with consistent subdivision by the same pathologists into invasive and non-invasive categories, due to differing interpretation of terminology defining invasion. In pulmonary adenocarcinomas with classic morphology, which comprise the majority of cases, there is good reproducibility in identifying a predominant pattern and fair reproducibility distinguishing invasive from in-situ (wholly lepidic) patterns. However, more precise definitions and better education on interpretation of existing terminology are required to improve recognition of purely in-situ disease, this being an area of increasing importance.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164925/en_US
dash.licenseLAA
dc.titleReproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver studyen_US
dc.typeJournal Articleen_US
dc.date.updated2017-09-22T13:16:14Z
dc.description.versionAccepted Manuscripten_US
dash.depositing.authorChirieac, Lucian
dc.date.available2012
dc.date.available2020-05-21T16:09:01Z
dc.identifier.doi10.1038/modpathol.2012.106
dc.source.journalMod Pathol
dash.source.volume25;12
dash.source.page1574-1583
dash.contributor.affiliatedChirieac, Lucian


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