A Dynamic Network Approach for the Study of Human Phenotypes

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A Dynamic Network Approach for the Study of Human Phenotypes

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Title: A Dynamic Network Approach for the Study of Human Phenotypes
Author: Christakis, Nicholas Alexander; Hidalgo, Cesar A; Blumm, Nicholas; Barabási, Albert-­‐László

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Citation: Hidalgo, César A., Nicholas Blumm, Albert-­László Barabási, and Nicholas Alexander Christakis. 2009. A dynamic network approach for the study of human phenotypes. PLoS Computational Biology 5(4): 1-11.
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Abstract: The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database summarizing correlations obtained from the disease history of more than 30 million patients in a Phenotypic Disease Network (PDN). We present evidence that the structure of the PDN is relevant to the understanding of illness progression by showing that (1) patients develop diseases close in the network to those they already have; (2) the progression of disease along the links of the network is different for patients of different genders and ethnicities; (3) patients diagnosed with diseases which are more highly connected in the PDN tend to die sooner than those affected by less connected diseases; and (4) diseases that tend to be preceded by others in the PDN tend to be more connected than diseases that precede other illnesses, and are associated with higher degrees of mortality. Our findings show that disease progression can be represented and studied
using network methods, offering the potential to enhance our understanding of the origin and evolution of human diseases. The dataset introduced here, released concurrently with this publication, represents the largest relational phenotypic resource publicly available to the research community.
Published Version: doi:10.1371/journal.pcbi.1000353
Other Sources: http://arxiv.org/ftp/arxiv/papers/0909/0909.3893.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:4276345
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