Show simple item record

dc.contributor.authorGuo, Yuchun
dc.contributor.authorEichler, Gabriel S.
dc.contributor.authorFeng, Ying
dc.contributor.authorIngber, Donald Elliott
dc.contributor.authorHuang, Sui
dc.date.accessioned2010-09-29T20:16:40Z
dc.date.issued2006
dc.identifier.citationGuo, Yuchun, Gabriel S. Eichler, Ying Feng, Donald E. Ingber, and Sui Huang. 2006. Towards a holistic, yet gene-centered analysis of gene expression profiles: A case study of human lung cancers. Journal of Biomedicine and Biotechnology 2006.en_US
dc.identifier.issn1110-7243en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4453993
dc.description.abstractGenome-wide gene expression profile studies encompass increasingly large number of samples, posing a challenge to their presentation and interpretation without losing the notion that each transcriptome constitutes a complex biological entity. Much like pathologists who visually analyze information-rich histological sections as a whole, we propose here an integrative approach. We use a self-organizing maps -based software, the gene expression dynamics inspector (GEDI) to analyze gene expression profiles of various lung tumors. GEDI allows the comparison of tumor profiles based on direct visual detection of transcriptome patterns. Such intuitive “gestalt” perception promotes the discovery of interesting relationships in the absence of an existing hypothesis. We uncovered qualitative relationships between squamous cell tumors, small-cell tumors, and carcinoid tumor that would have escaped existing algorithmic classifications. These results suggest that GEDI may be a valuable explorative tool that combines global and gene-centered analyses of molecular profiles from large-scale microarray experiments.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.isversionofdoi:10.1155/JBB/2006/69141en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698264/pdf/en_US
dash.licenseLAA
dc.titleTowards a Holistic, Yet Gene-Centered Analysis of Gene Expression Profiles: A Case Study of Human Lung Cancersen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalJournal of Biomedicine and Biotechnologyen_US
dash.depositing.authorIngber, Donald Elliott
dc.date.available2010-09-29T20:16:40Z
dc.identifier.doi10.1155/JBB/2006/69141*
dash.contributor.affiliatedIngber, Donald


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record