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dc.contributor.authorNewton, Irene Lucile Garcia
dc.contributor.authorGirguis, Peter R.
dc.contributor.authorCavanaugh, Colleen Marie
dc.date.accessioned2010-09-29T20:22:14Z
dc.date.issued2008
dc.identifier.citationNewton, Irene LG., Peter R. Girguis, and Colleen M. Cavanaugh. 2008. Comparative genomics of vesicomyid clam (Bivalvia: Mollusca) chemosynthetic symbionts. BMC Genomics 9: 585.en_US
dc.identifier.issn1471-2164en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4453996
dc.description.abstractBackground: The Vesicomyidae (Bivalvia: Mollusca) are a family of clams that form symbioses with chemosynthetic gamma-proteobacteria. They exist in environments such as hydrothermal vents and cold seeps and have a reduced gut and feeding groove, indicating a large dependence on their endosymbionts for nutrition. Recently, two vesicomyid symbiont genomes were sequenced, illuminating the possible nutritional contributions of the symbiont to the host and making genome-wide evolutionary analyses possible. Results: To examine the genomic evolution of the vesicomyid symbionts, a comparative genomics framework, including the existing genomic data combined with heterologous microarray hybridization results, was used to analyze conserved gene content in four vesicomyid symbiont genomes. These four symbionts were chosen to include a broad phylogenetic sampling of the vesicomyid symbionts and represent distinct chemosynthetic environments: cold seeps and hydrothermal vents. Conclusion:The results of this comparative genomics analysis emphasize the importance of the symbionts' chemoautotrophic metabolism within their hosts. The fact that these symbionts appear to be metabolically capable autotrophs underscores the extent to which the host depends on them for nutrition and reveals the key to invertebrate colonization of these challenging environments.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2164-9-585en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642828/pdf/en_US
dash.licenseOAP
dc.titleComparative Genomics of Vesicomyid Clam (Bivalvia: Mollusca) Chemosynthetic Symbiontsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Genomicsen_US
dash.depositing.authorGirguis, Peter R.
dc.date.available2010-09-29T20:22:14Z
dc.identifier.doi10.1186/1471-2164-9-585*
dash.contributor.affiliatedNewton, Irene
dash.contributor.affiliatedCavanaugh, Colleen
dash.contributor.affiliatedGirguis, Peter


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