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dc.contributor.authorYuan, Guo-Cheng
dc.contributor.authorMa, Ping
dc.contributor.authorZhong, Wenxuan
dc.contributor.authorLiu, Jun
dc.date.accessioned2010-09-30T14:11:32Z
dc.date.issued2006
dc.identifier.citationYuan, Guo-Cheng, Ping Ma, Wenxuan Zhong, and Jun S. Liu. 2006. Statistical assessment of the global regulatory role of histone acetylation. Genome Biology 7(8): R70.en_US
dc.identifier.issn1465-6906en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4454174
dc.description.abstractBACKGROUND: Histone acetylation plays important but incompletely understood roles in gene regulation. A comprehensive understanding of the regulatory role of histone acetylation is difficult because many different histone acetylation patterns exist and their effects are confounded by other factors, such as the transcription factor binding sequence motif information and nucleosome occupancy. RESULTS: We analyzed recent genomewide histone acetylation data using a few complementary statistical models and tested the validity of a cumulative model in approximating the global regulatory effect of histone acetylation. Confounding effects due to transcription factor binding sequence information were estimated by using two independent motif-based algorithms followed by a variable selection method. We found that the sequence information has a significant role in regulating transcription, and we also found a clear additional histone acetylation effect. Our model fits well with observed genome-wide data. Strikingly, including more complicated combinatorial effects does not improve the model's performance. Through a statistical analysis of conditional independence, we found that H4 acetylation may not have significant direct impact on global gene expression. CONCLUSION: Decoding the combinatorial complexity of histone modification requires not only new data but also new methods to analyze the data. Our statistical analysis confirms that histone acetylation has a significant effect on gene transcription rates in addition to that attributable to upstream sequence motifs. Our analysis also suggests that a cumulative effect model for global histone acetylation is justified, although a more complex histone code may be important at specific gene loci. We also found that the regulatory roles among different histone acetylation sites have important differences.en_US
dc.description.sponsorshipStatisticsen_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/gb-2006-7-8-r70en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779595/pdf/en_US
dash.licenseLAA
dc.titleStatistical Assessment of the Global Regulatory Role of Histone Acetylation in Saccharomyces cerevisiaeen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Biologyen_US
dash.depositing.authorLiu, Jun
dc.date.available2010-09-30T14:11:32Z
dc.identifier.doi10.1186/gb-2006-7-8-r70*
dash.contributor.affiliatedLiu, Jun


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