A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency
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A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency
| Title: | A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency |
| Author: |
Artyomov, Maxim N.; Chakraborty, Arup K.; Meissner, Alexander
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Artyomov, Maxim N., Alexander Meissner, and Arup K. Chakraborty. 2010. A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency. PLoS Computational Biology 6(5): e1000785. |
| Full Text & Related Files: |
2869311.pdf (1.094Mb; PDF) 
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| Abstract: | With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells for patient-specific regenerative medicine. We have developed a computational model for the architecture of the epigenetic and genetic regulatory networks which describes transformations resulting from expression of reprogramming factors. Importantly, our studies identify the rare temporal pathways that result in induced pluripotent cells. Further experimental tests of predictions emerging from our model should lead to fundamental advances in our understanding of how cellular identity is maintained and transformed. |
| Published Version: | doi:10.1371/journal.pcbi.1000785 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869311/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4454183 |
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