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dc.contributor.authorZou, Lihua
dc.contributor.authorSriswasdi, Sira
dc.contributor.authorRoss, Brian D
dc.contributor.authorMissiuro, Patrycja V.
dc.contributor.authorLiu, Jun
dc.contributor.authorGe, Hui
dc.contributor.authorSidow, Arend
dc.date.accessioned2010-09-30T17:21:26Z
dc.date.issued2008
dc.identifier.citationZou, Lihua, Sira Sriswasdi, Brian Ross, Patrycja V. Missiuro, Jun Liu, Hui Ge, and Arend Sidow. 2008. Systematic analysis of pleiotropy in early embryogenesis. PLoS Computational Biology 4(2): e1000003.en_US
dc.identifier.issn1553-734Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4454677
dc.description.abstractPleiotropy refers to the phenomenon in which a single gene controls several distinct, and seemingly unrelated, phenotypic effects. We use C. elegans early embryogenesis as a model to conduct systematic studies of pleiotropy. We analyze high-throughput RNA interference (RNAi) data from C. elegans and identify “phenotypic signatures”, which are sets of cellular defects indicative of certain biological functions. By matching phenotypic profiles to our identified signatures, we assign genes with complex phenotypic profiles to multiple functional classes. Overall, we observe that pleiotropy occurs extensively among genes involved in early embryogenesis, and a small proportion of these genes are highly pleiotropic. We hypothesize that genes involved in early embryogenesis are organized into partially overlapping functional modules, and that pleiotropic genes represent “connectors” between these modules. In support of this hypothesis, we find that highly pleiotropic genes tend to reside in central positions in protein-protein interaction networks, suggesting that pleiotropic genes act as connecting points between different protein complexes or pathways.en_US
dc.description.sponsorshipStatisticsen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pcbi.1000003en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265476/pdf/en_US
dash.licenseLAA
dc.subjectcomputational biologyen_US
dc.subjectsystems biologyen_US
dc.subjectdevelopmental biologyen_US
dc.titleSystematic Analysis of Pleiotropy in C. elegans Early Embryogenesisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Computational Biologyen_US
dash.depositing.authorLiu, Jun
dc.date.available2010-09-30T17:21:26Z
dc.identifier.doi10.1371/journal.pcbi.1000003*
dash.contributor.affiliatedRoss, Brian D
dash.contributor.affiliatedLiu, Jun


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