| dc.contributor.author | Veerapen, Natacha | |
| dc.contributor.author | Brigl, Manfred | |
| dc.contributor.author | Garg, Salil | |
| dc.contributor.author | Cerundolo, Vincenzo | |
| dc.contributor.author | Cox, Liam R. | |
| dc.contributor.author | Brenner, Michael Barry | |
| dc.contributor.author | Besra, Gurdyal S. | |
| dc.date.accessioned | 2010-09-30T17:26:04Z | |
| dc.date.issued | 2009 | |
| dc.identifier.citation | Veerapen, Natacha, Manfred Brigl, Salil Garg, Vincenzo Cerundolo, Liam R. Cox, Michael B. Brenner, and Gurdyal S. Besra. 2009. Synthesis and biological activity of α-galactosyl ceramide KRN7000 and galactosyl (α1→2) galactosyl ceramide. Bioorganic & Medicinal Chemistry Letters 19(15): 4288-4291. | en_US |
| dc.identifier.issn | 0960-894X | en_US |
| dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4454679 | |
| dc.description.abstract | We herein report a faster and less cumbersome synthesis of the biologically attractive, α-galactosyl ceramide (α-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(α1→2)GalCer, which has been shown to require uptake and processing to the biologically active α-GalCer derivative. | en_US |
| dc.description.sponsorship | Engineering and Applied Sciences | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier Science Ltd | en_US |
| dc.relation.isversionof | doi:10.1016/j.bmcl.2009.05.095 | en_US |
| dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722241/pdf/ | en_US |
| dash.license | OAP | |
| dc.title | Synthesis and Biological Activity of α-Galactosyl Ceramide KRN7000 and Galactosyl (α1→2) Galactosyl Ceramide | en_US |
| dc.type | Journal Article | en_US |
| dc.description.version | Accepted Manuscript | en_US |
| dc.relation.journal | Bioorganic & Medicinal Chemistry Letters | en_US |
| dash.depositing.author | Brenner, Michael Barry | |
| dc.date.available | 2010-09-30T17:26:04Z | |
| dc.identifier.doi | 10.1016/j.bmcl.2009.05.095 | * |
| dash.contributor.affiliated | Brigl, Manfred | |
| dash.contributor.affiliated | Garg, Salil | |
| dash.contributor.affiliated | Brenner, Michael | |
